Suggest the effects of each of the following mutations on the physiological role of chymotrypsinogen: 1) R15S: a) Activation of the molecule will be greatly reduced due to removal of the R that is binded in its active site

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Suggest the effects of each of the following mutations on the physiological role of chymotrypsinogen:

1) R15S:

a) Activation of the molecule will be greatly reduced due to removal of the R that is binded in its active site.

b) Automodification of π-chymotrypsin to α-chymotrypsin could be reduced, the effect on activation might be slight.

c) If activation occurs, the N-terminal peptide will no longer be constrained by an SS bond and may be released.

2) C1S:

a) Activation of the molecule will be greatly reduced due to removal of the R that is binded in its active site.

b) Automodification of π-chymotrypsin to α-chymotrypsin could be reduced, the effect on activation might be slight.

c) If activation occurs, the N-terminal peptide will no longer be constrained by an SS bond and may be released.

3) T147S:

a) Activation of the molecule will be greatly reduced due to removal of the R that is binded in its active site.

b) Automodification of π-chymotrypsin to α-chymotrypsin could be reduced, the effect on activation might be slight.

c) If activation occurs, the N-terminal peptide will no longer be constrained by an SS bond and may be released.