question archive Compare contrast PT and APTT diagnostic tests

Compare contrast PT and APTT diagnostic tests

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Compare contrast PT and APTT diagnostic tests. Explain briefly how they are prepared and what information is gained.

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Answer:

The differences can be as discussed ahead:

PT test (Prothrombin time) aPTT Test (Activated Partial thromboplastin time)
A cumulative biochemical test which quantifies the exact homeostatic concentration of all factors required for optimum thrombus or blood clot formation. A biochemical test which quantifies only body's self molecules which are explicitly required for thrombus formation.
It is based upon analyzing problems in clotting associated with the extrinsic pathway of thrombus formation. It is largely based upon analyzing the problems associated with the intrinsc pathway of thrombus formation.
Factors targeted include mainly VII, VIIa, and TF Factors targeted mainly include XII, XIIa, XI and IX

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