question archive DISORDER UNDERLYING ABNORMALITY PT TIME APTT TIME PLATELET COUNT TEMPLATE BLEEDING TIME ITP ET Bernard-Soulier VWD Disease Glanzmann Storage pool disease Hemophilia A Factor X Deficiency For each of the listed disorders, fill in the following data in the table below
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DISORDER |
UNDERLYING ABNORMALITY |
PT TIME |
APTT TIME |
PLATELET COUNT |
TEMPLATE BLEEDING TIME |
ITP |
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ET |
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Bernard-Soulier |
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VWD Disease |
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Glanzmann |
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Storage pool disease |
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Hemophilia A |
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Factor X Deficiency |
For each of the listed disorders, fill in the following data in the table below.
Answer:
Normal range
Platelet count = 1.5-4.5 lac/mm3 PT time = 9 to 14 seconds
APTT time= 35 to 45 seconds Bleeding time = 2 to 6 minutes
Disorder |
Underlying abnormality |
PT time |
APTT time |
Platelet Count |
Template Bleeding time |
ITP |
Normally blood does not clot (immune system produce the antibodies against the platelets) |
Normal |
Prolong |
Very low |
Prolong |
ET |
Megakaryocytic metaplasia ( megakaryocytes produce more platelets) |
Normal |
Prolong |
High |
Prolong |
Bernard Soulier |
Due to deficiency of glycoprotein Ib (GPIb), the receptor for binding of blood clotting factor-VIII |
Normal |
Prolong |
Low |
Prolong |
VWD Disease |
Lack of blood clotting factor- VIII (von Willebrand factor (VWF) |
Normal |
Normal to prolong |
Normal |
Prolong |
Glanzmann |
Due to deficiency of glycoprotein IIb (GpIIb/IIIa) a receptor for fibrinogen |
Normal |
Prolong |
Normal |
Prolong |
Storage pool disease |
Platelet granules are affected |
Normal |
Prolong |
Below or normal |
Prolong |
Hemophilia- A |
Due to genetic deficiency in clotting factor VIII |
Normal |
Prolong |
Normal |
Normal |
Factor-X deficiency |
Lack or deficiency of blood clotting factor-X in the blood circulation |
Prolong |
Prolong |
Normal |
Prolong |