question archive DISORDER UNDERLYING ABNORMALITY PT TIME APTT TIME PLATELET COUNT TEMPLATE BLEEDING TIME ITP           ET           Bernard-Soulier           VWD Disease           Glanzmann           Storage pool disease           Hemophilia A           Factor X Deficiency           For each of the listed disorders, fill in the following data in the table below

DISORDER UNDERLYING ABNORMALITY PT TIME APTT TIME PLATELET COUNT TEMPLATE BLEEDING TIME ITP           ET           Bernard-Soulier           VWD Disease           Glanzmann           Storage pool disease           Hemophilia A           Factor X Deficiency           For each of the listed disorders, fill in the following data in the table below

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DISORDER

UNDERLYING ABNORMALITY

PT TIME

APTT TIME

PLATELET COUNT

TEMPLATE BLEEDING TIME

ITP

         

ET

         

Bernard-Soulier

         

VWD Disease

         

Glanzmann

         

Storage pool disease

         

Hemophilia A

         

Factor X Deficiency

         

For each of the listed disorders, fill in the following data in the table below.

  1. The specific molecular/cellular abnormalities that underlie the disorder.
  2. The expected diagnostic results of PT time, APTT time, Platelet count, and Template bleeding time as either: Normal (N), Increased (I), or Decreased (D).

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Answer:

Normal range

Platelet count = 1.5-4.5 lac/mm3 PT time = 9 to 14 seconds   

APTT time= 35 to 45 seconds   Bleeding time = 2 to 6 minutes

Disorder

Underlying abnormality

PT time

APTT time

Platelet Count

Template Bleeding time

ITP

Normally blood does not clot (immune system produce the antibodies against the platelets)

Normal

Prolong

Very low

Prolong

ET

Megakaryocytic metaplasia ( megakaryocytes produce more platelets)

Normal

Prolong

High

Prolong

Bernard Soulier

Due to deficiency of glycoprotein Ib (GPIb), the receptor for binding of blood clotting factor-VIII

Normal

Prolong

Low

Prolong

VWD Disease

Lack of blood clotting factor- VIII (von Willebrand factor (VWF)

Normal

Normal to prolong

Normal

Prolong

Glanzmann

Due to deficiency of glycoprotein IIb (GpIIb/IIIa) a receptor for fibrinogen

Normal

Prolong

Normal

Prolong

Storage pool disease

Platelet granules are affected

Normal

Prolong

Below or normal

Prolong

Hemophilia- A

Due to genetic deficiency in clotting factor VIII

Normal

Prolong

Normal

Normal

Factor-X deficiency

Lack or deficiency of blood clotting factor-X in the blood circulation

Prolong

Prolong

Normal

Prolong