question archive You become a part of a research lab that studies the connection between cell signaling pathways and cancer development in breast and prostate cells
You become a part of a research lab that studies the connection between cell signaling pathways and cancer development in breast and prostate cells
Subject:BiologyPrice: Bought3
You become a part of a research lab that studies the connection between cell signaling pathways and cancer development in breast and prostate cells. You are asked the following: A) Your knowledge of protein folding and GPCR structure/fu nation to make three predictions about the probable features of a GPCR’s primary amino acid sequence. List the features you selected and explain why you chose them. B) You are next given some literature to review. One of the papers you read describes a large dataset where the mRNA levels of different GPCRs were quanti?ed. In this study, it was found that 45 different GPCRs had higher levels of transcript in cancer cells vs. normal cells, but the authors acknowledge that they did not determine whether or not the levels of GPCR protein are also higher in the cancerous cells. Explain why this distinction matters, and then describe an experiment that you might propose in order to follow up on their data. C) You summarize the literature you reviewed and present the results to your grad student mentor, who is really surprised when you tell them that while the study identified 45 upregulated GPCRs in breast cancer and prostate cells, only one of the GPCRs identified in the study were upregulated in BOTH breast cancer AND prostate cancer cells. Use what you know about cell signaling to explain why this result is not surprising to you.
