1) The two pathways - Gluconeogenesis and Glycolysis, are reciprocally regulated in liver cells, meaning only one pathway is active at a time

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1) The two pathways - Gluconeogenesis and Glycolysis, are reciprocally regulated in liver cells, meaning only one pathway is active at a time. Briefly describe the goal of each of these pathways. Then explain the importance of regulating these two pathways in this way. 2) One way that insulin signaling regulates metabolism is by activating an enzyme that produces an allosteric regulator of Phosphofructokinase (PFK). Explain the role and importance of PFK in metabolism. Then predict whether allosteric regulation induced by insulin will activate or repress PFK activity. 3) PFK is inhibited when ATP and citrate (an intermediate in the TCA cycle) are abundant inside the cell. Explain the metabolic connection between high [ATP] and high [citrate] (i.e. how does one affect the other?). Then explain the metabolic logic of using these molecules to inhibit PFK