question archive Cancer-related genes can be classified into two major groups
Cancer-related genes can be classified into two major groups
Subject:BiologyPrice: Bought3
Cancer-related genes can be classified into two major groups. Oncogenes encode proteins
that normally act in promoting cell growth and proliferation. Gain-of-function mutations in
oncogenes can therefore transform the cells into a cancerous state. Tumor suppressor genes,
on the other hand, encode proteins that normally function to keep cell proliferation in check.
Thus, loss-of-function mutations in tumor suppressors can lead to cancer by eliminating the
inhibitory effect of these genes. Mutations in genes encoding the components of the canonical Wnt signaling pathway are commonly found in colorectal tumors. Thinking about how Wnt signaling controls stem cell differentiation and cell division in the gut, indicate whether the following genes would be characterized as a oncogene or tumor suppressor. Briefly explain your answers.
a. Wnt
b. APC
c. Beta-Catenin
