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question archive 1) Some interventions, such as defibrillation for ventricular fibrillation, have an impact so large that observational data are sufficient to show it

1) Some interventions, such as defibrillation for ventricular fibrillation, have an impact so large that observational data are sufficient to show it

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1) Some interventions, such as defibrillation for ventricular fibrillation, have an impact so large that observational data are sufficient to show it.

2) Infrequent adverse outcomes would be detected only by RCTs so large that they are rarely conducted. Observational methods such as post-marketing surveillance of medicines are the only alternative.

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