How does the nicotine from cigarette smoking disrupt oxygen distribution to the cells?   It restricts air flow through the bronchi

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How does the nicotine from cigarette smoking disrupt oxygen distribution to the cells?

 

1. It restricts air flow through the bronchi.
2. It reduces the surface area of the alveolar sacs.
3. It binds to hemoglobin in red blood cells.
4. It affects the nerve signals that regulate breathing.