There are a number of drugs on the market to manage diabetes

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There are a number of drugs on the market to manage diabetes. They have different mechanisms of action. Here are a few with a short description of how they work.

Sulfonylureas are drugs that stimulate insulin secretion from beta cells. Tolbutamide is an example of a sulfonylurea, although newer sulfonylureas such as glibenclamide are more commonly used instead.

Metformin (Glucophage) is a drug that is cheap and generally safe and effective. It works to limit 'hepatic glucose production', in part by inhibiting gluconeogenesis.

4a) What metabolic state is typically associated with increased hepatic glucose production?

Absorptive state/post-absorptive state

Thiazolidinediones (TZDs) improve/restore insulin action, or promote the sensitivity of target cells for insulin.

4b) Almost all cells of our body have insulin receptors and can respond to insulin. However, from a whole body perspective, name the 3 organs that are the most important targets of insulin.

Answer