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Great discussion post. I enjoyed reading it. It is quite a challenge combined with other comorbidities that have often been treated with a mental issue. Zyprexa appeared effective in controlling the patient's psychosis. Olanzapine (OLZ) is a second-generation antipsychotic drug. It is mostly to treat schizophrenia, bipolar disorder, and other neuropsychiatric conditions. The significant side effects or adverse reactions of OLZ include metabolic alterations weight gain associated with chronic oxidative-inflammation events. Alterations related to regular oxidative-inflammation events. Lithium (Li), a mood modulator that exhibits anti-inflammatory properties, may diminish OLZ-induced oxi-inflammatory effects. (Fernandes et al., 2019).

Zyprexa can be taken in tablets, orally disintegrating tablets, or as an injection. Other common effects of olanzapine include constipation, dry mouth, low blood pressure, and feeling dizzy, drowsy, or restless. Gender and smoking habits were found to be significant covariates that influence the clearance of olanzapine.

Close to 19 million US adults have severe mental illnesses (SMI), and they die, on average, 25 years earlier than the general population, most often from cardiovascular disease (CVD). Many antipsychotic medications are used to treat several mental illnesses, which also contribute to CVD risk by increasing the risk of obesity, type 2 diabetes, dyslipidemia, and hypertension. The recommendations include reducing antipsychotic medication dose or switching antipsychotic medications. Enhancing smoking cessation efforts, sharing electronic health records between physical and mental health care systems, and promoting care integration (Mangurian et al., 2016).

Zyprexa concerns the risk of diabetes, Indication of diabetes cases in people utilizing the drug; the significance of the drug for schizophrenia and bipolar mania. Because Zyprexa affects increased appetite, we usually give out po or injection as prn bases at my work. 

 

Thank you for your initial post this week's discussion regarding Clozapine for the treatment of Schizophrenia. A lot of times if a patient comes in with psychiatric issues, they are looked over even though it has been proven that psychiatric patients has quite a few medical comorbidities.

I agreed that for a patient with Clozapine, lab tests are carried out close to monitor the pharmacodynamics mechanism and the side effects of the drug. Clozapine treatment is scheduled if the patient has a lower absolute neutrophil count (ANC) threshold than before the medication's prescription. Plasma levels for patients on Clozapine should range between 250-350mg/ml. Maintenance doses range between 300-600mg/day for efficacy purposes (Vollm & Huband, 2017).

The initial dosage for Clozapine is 12.5-25mg/day, to be taken twice or three per day to minimize autonomic side effects. Clozapine is also safe, significantly who patients delayed recovery upon prescription with another antipsychotic drug (Gillespie et al. n.d.).

Health care providers should prioritize their patients' medical needs and, as appropriate, prescribing, and dispensing Clozapine to patients with an absolute neutrophil count within the acceptable ranges. At the same time, the issues are resolved by the Clozapine Risk Evaluation and Mitigation Strategy (REMS) program for Clozapine to improve hematologic events' safety monitoring. The FDA has rigid treatment guidelines for hematologic monitoring for clozapine patients. Program administrators. Prescribers and pharmacies should collaborate with the Clozapine REMS Program administrators to resolve any problems and ongoing their efforts to complete certification and update patient information to meet the program's requirements (Clozapine REMS deadlines for prescribers and pharmacies extended, 2016).

 

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