Choose 2 of the following to answer in as much detail as possible

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Choose 2 of the following to answer in as much detail as possible. Please be sure to number your answers.  

1. Discuss and describe in detail the different categories of viral vectors. Discuss when and how they are used in gene therapy and the advantages and/or disadvantages of each.
2. Discuss the importance of drug interactions due to cytochrome P450 isozymes and the implications for gene therapy. Give specific examples!
3. Discuss in detail genome editing. Includes the engineered nucleases used and their use in NHEJ or HDR. Also include how each is currently used in gene/cell therapies.