question archive Today, you learned about blood components, plasma, and hemostasis reaction cascade
Today, you learned about blood components, plasma, and hemostasis reaction cascade
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Today, you learned about blood components, plasma, and hemostasis reaction cascade. Use what you learned in this lecture to answer these 2 questions:
1. When you read the testimonials and memoirs of survivors of WWII concentration camps, many of them mention that the weight loss form severe malnutrition was quite remarkable, and yet, their ankles and feet would get so swollen that walking would become difficult. How do you explain the swelling in the lower extremities in the concentration camp victims? (hint: it has something to do with albumin)
2. Aspirin is known for its blood-thinning action. How, do you think, it works? Be specific, and point out, at which step of hemostasis aspirin interferes with thrombogenesis reaction cascade and inhibits the production of blood clots
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Answer:
1. The survivors suffered malnutrition therefore this led to development of hypoalbuminemia. This low level of albumin in the blood resulted to decreased oncotic pressure and hence high hydrostatic pressure which thus resulted into extravasation of fluids from blood vessels resulting into edema.
In Malnutrition there decreased intake of amino acids hence reduced synthesis of albumin causing hypoalbuminemia.
2. Aspirin is a blood thinning agent - which act as a antiplatelet agent. It prevents the aggregation of platelets hence inhibiting formation of blood clot.
Aspirin is a Cyclooxygenase enzyme inhibitors, it inhibits formation of thromboxane A2. This inhibits platelets activation hence preventing platelet aggregation. This prevents formation of the platelet plug.
