A recent research study published in The Journal of Biological Chemistry (2020) and mentioned in Science Daily (2020) discussed a drug that had been used in the treatment of SARS and MERS type coronaviruses. Recently, NIH funded research (2020) at The University of Nebraska Medical Center (UNMC) was being conducted to test for this compound's effectiveness in the early stages of the COVID- 19 pandemic. Please review the articles below and answer the following questions. Keep your answers concise. https://www.sciencedaily.com/releases/2020/02/2002 27122 123.htm https://www.jbc.org/article/S0021-9258(17)485 74-7/fulltext . . https://www.nih.gow/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins (a) (1pt) What is the name of the drug discussed? (b) (i) (1pt) Look up (ie. google) and draw the structure of this drug. (ii) How many carbon atoms in this structure are considered chiral? Circle each chiral carbon. (1 pts) (c) (i) (1pt) What is the absolute (R/S) configuration of the chiral carbon that IS NOT also part of a ring? Circle the correct label (R or S) below. (ii) (Ipt) Show your priorities the using the structure you drew in part (b) that led you to this answer. R configuration or S configuration (d) (1pt) How many total stereoisomers exists for this compound (including the one shown above)? (Note, the phosphorous in this structure is also a stereocenter). total stereoisomers (e) (i) (1pts) Why does the stereochemistry of this compound matter? (ii) (1pt) What biochemical enzyme has this drug been shown to inhibit and why is this important in the fight against viral infection? (f) (2pt) Draw the structure and provide a name of the RNA nucleotide that this drug most closely resembles.

pur-new-sol

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