Certain villages in India are very conservative where their women are required to wear clothes that completely cover up their entire body. Unfortunately, these females experience bone pain, fractures, muscle weakness and depression. Please explain the relationship between their attire and the signs and symptoms they experience. Explain Physiology. Explain the process of Vitamin D synthesis in depth. Explain Correlation. What is the correlation between her clothes and lack of Vitamin D.

Explanation and support your answer with facts from your textbook, research and / or articles from scholarly journals). Add references.

Vitamin D is produced by photolysis from natural sterol precursors, this is "photolysis" need of UV light that can be obtained from direct exposure to the sun. Although it's said to be a vitamin is properly considered as a hormone because it can be formed in vivo. The process of synthesis is:

1)The skin has a 7-dehydrocholesterol in the dermis and epidermis that when exposed to UV (280-320 nm) light is converted into previtamin D3.

1. Then with a thermostable process, the pre-vitamin D is converted into vitamin D3 (cholecalciferol), it can also be done with lumisterol and tachysterol.2)
2. After that this vitamin travels to the liver (with BDP as it's binding protein) where it is metabolized into 25-hydroxycholecalciferol by mitochondrial enzyme CYP27A1.
3. Then in kidneys, is further metabolized to 1,25-dihydroxicholecalciferol that is the active form of the vitamin D this is done by the mitochondrial enzyme CYP27B2. In this step, other things have influenced these include: PTH, calcium, and phosphorus.

Vitamin D has four main functions:

1. Intestinal calcium transport: It allows the intestine to absorb calcium if needed.
2. Actions on vitamin D in the bone: It regulates the formation of the bone and the reabsorption of calcium in them. It makes the calcium able to bind and form the bone.
3. Actions in the kidneys: It enables calcium reabsorption.
4. Other tissues: It regulates the production and secretion of certain hormones including insulin and prolactin. Suppress the immune system, Modulate contractibility and vascular tone, reduces the rate of proliferation of many cell lineages, among others,

Although it has many functions the more important is the regulation of the concentration of calcium in the body. This is important because calcium has many important functions including.

1. Formation and strength of bones
2. Coagulation and cloth formation
3. Nerves signals
4. Relaxation and contraction of muscles
5. Regulation of hormones and other chemicals.

Now, focusing on the women of India we can say that as they have no direct contact with the UV of the sunlight because they are all covered up in clothes. This makes it impossible to convert 7-dehydrocholesterol into pre-vitamin D and proceed with the pathway. Without vitamin D calcium would be very low in the body. And with this, we can explain the different signs and symptoms that these women have. First, bone pain and fractures, are caused due to the low amount of calcium in the body and the lack of vitamin D that enables the reabsorption of calcium in the bones. IN other words, this causes fragile bones that make fractures recurrent and causes bone pain. The muscle weakness is caused because calcium is needed for muscle contraction and relaxation. At last, the depression is caused because calcium and vitamin D are needed for the production of neurotransmitters, and for neuron signaling if something of these fails different neural imbalances can lead to depression.