Compare the four kinds of gated channels in terms of the factor that opens or closes them.

Ligand-gated ion channels are ionotropic receptors that open and close in response to a chemical messenger. Such a messenger is a neurotransmitter. Their permeability is increased when a ligand binds to a protein.

Step-by-step explanation

Voltage-gated channels are selective for a selective ion such as sodium or potassium, which controls how they open and close. The potential of the membrane influences their permeability.

 Mechano-sensitive channels detect the external forces into chemical or electrical intracellular signals. They regulate blood pressure, stimulate bone and muscle development, and enhance the sense of touch and hearing.

A leak channel is randomly gated, and it opens and closes at random without any factor regulating it. The opening and closing of this channel happen at an intrinsic rate.