question archive Hurler syndrome is an autosomal recessive disease caused by a deficiency of the enzyme alpha-L-iduronidase
Hurler syndrome is an autosomal recessive disease caused by a deficiency of the enzyme alpha-L-iduronidase
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Hurler syndrome is an autosomal recessive disease caused by a deficiency of the enzyme alpha-L-iduronidase. Affected individuals are mentally retarded, and they have skeletal abnormalities and short stature. The population incidence is about 1 in 90,000.
a. Calculate the allelic and genotypic frequencies for the disease assuming Hardy-Weinberg equilibrium. Show your work and express your answer to three significant figures.
Answer:
b. What would be the increased risk of Hurler syndrome among the offspring of first-cousin matings? Show your work and express your final answer to three significant figures.
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