question archive Salicylamide is an active ingredient in BC powder
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Salicylamide is an active ingredient in BC powder. What is its purpose?
Consider the directing effects of the substituents on salicylamide and predict the possible structures of the iodination products. Which do you think will be the major product? Explain your reasoning.
Salicylamide is an amide of salicylic acid. It is an active ingreadient of BC powder enhancing the plasma level of aspirin level which increases its therapeutic value..
The -CONH2 is a meta-directing group, therefore the electrophilic aromatic substitution reaction adds I to the meta-position. The -CO group pulls electron from the benzene ring, aking it less electron rich and therefore, substitution occurs at meta to -CONH2 but para to -OH group.