Joseph is a 57-year-old male with newly dx end stage lung disease with metastasis to the brain

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Joseph is a 57-year-old male with newly dx end stage lung disease with metastasis to the brain. He has undergone radiation therapy to the brain for his metastases and is starting chemotherapy next week. He has a history of Hypertension and no known drug allergies. He is experiencing N&V from the chemotherapy. 

What drug therapy would you prescribe and why