question archive A tumor cell with a mutation in Rbabsence can divide in the of extracellular signals
A tumor cell with a mutation in Rbabsence can divide in the of extracellular signals
Subject:BiologyPrice: Bought3
A tumor cell with a mutation in Rbabsence can divide in the of extracellular signals.
A. If the Rb mutation is responsible for the increased cell division, is it likely that Rb is always active or always inactive?
Explain your reasoning.
B. Which of the following molecules would be likely to block division of these tumor cells? Select all that would block division in cells with this Rb mutation
a. An inhibitor of Ras GEF
b. A MAPK inhibitor
c. An inhibitor of the G1 checkpoint Cdk
d. An inhibitor of E2F (transcription factor regulated by Rb)
e. An inhibitor of DNA polymerase
C. Explain why the choice/one choice in part B would block division of cells expressing this Rb mutant.
D. Explain why one of the choices in part B that you did NOT select would NOT block cell division in cell expressing this Rb mutant.
